MAKATUSSIN SYROP SECRETS

desvenlafaxine will increase the amount or impact of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Warning/Check. Desvenlafaxine inhibits CYP2D6; with increased desvenlafaxine doses (ie, 400 mg) reduce the CYP2D6 substrate dose by as many as 50%; no dosage adjustment essential with desvenlafaxine doses 7 consecutive times quickly prior